# Director / Senior Director, Lab-in-the-Loop at Altos Labs

- Company: Altos Labs
- What the company does: Altos Labs is a biotechnology company focused on restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that occur throughout life. Learn more about Altos. Backed by General Catalyst.
- Company website: https://altoslabs.com/
- Type: Startups
- Level: Principal and up
- Location: San Francisco Bay Area, CA;San Diego, CA
- Work setup: On-site
- Pay: $348K to $446K base salary per year (USD)
- Posted: 2026-09-24
- Apply by: 2026-11-08
- Apply: https://job-boards.greenhouse.io/altoslabs/jobs/6189235004
- Page: https://www.1752.vc/careers/jobs/altos-labs-director-senior-director-lab-in-the-loop/

## About the role

The rate limit on ML for biology is rarely the model. It is the loop between what the lab measures and what the model needs. Altos is looking for a Director or Senior Director-level scientist to own that loop across in vitro and in vivo systems: closed-loop systems where predictions steer the next experiment and results retrain the model, and rigorous standalone verification of model outputs where the wet-lab design still has to hold up.

## What they're looking for

- PhD (or equivalent) in a relevant field - genomics, systems biology, bioengineering, or a related discipline - with 10+ years of post-PhD experience, including senior leadership roles
- Deep hands-on experience designing large-scale perturbation or functional genomics experiments for downstream computational modeling, not as standalone biology
- Working fluency in ML concepts relevant to biological data, sufficient for substantive technical dialogue with ML leads
- A clear grasp of how choices in experimental design determine what a model can and cannot learn from the resulting data — and the judgment to design experiments accordingly
- Sound judgment on build-vs-buy decisions for assays, tools, and models, plus direct experience managing CROs and external vendor relationships
- Experience building, leading, and growing a technical team, alongside a track record of building or scaling experimental-computational feedback loops

Tags: Institute of Computation