# Principal Research Associate, Protein Engineering at Arbor Software

- Company: Arbor Software
- What the company does: Who we are. Arbor Biotechnologies, a clinical stage, next-generation gene editing company based in Cambridge, MA, is advancing a portfolio of first-in-class genomic medicines addressing serious diseases for which there are no existing functional cures, with a... Backed by Accel.
- Company website: https://www.arbor.eco
- Type: Startups
- Level: Principal and up
- Location: Cambridge, MA
- Work setup: On-site
- Pay: $95K to $110K base salary per year (USD)
- Posted: 2026-11-06
- Apply by: 2026-12-21
- Apply: https://ats.rippling.com/arbor/jobs/824c6f63-626f-4c7b-99d8-7745488432b6?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/arbor-software-principal-research-associate-protein-engineering/

## About the role

Our protein engineering campaigns are how Arbor’s editing tools get better. More precise, more deliverable, more effective in the cells that matter. This role generates and tests the variants that tell us what’s working. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Execute and optimize molecular biology and cell-based experiments supporting protein engineering campaigns, troubleshooting production, delivery, and assay performance as issues arise
- Generate and evaluate protein mutants and variants for genome editing applications
- Run cell-based screening workflows, including transient transfection, nucleofection, and transduction in dividing and non-dividing cell models
- Design, package, and test AAVs for variant evaluation
- Synthesize, purify, characterize, and test IVT-generated mRNA
- Prepare sequencing libraries and support analysis of editing outcomes, variant performance, and assay quality

Tags: Research

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/arbor-software-principal-research-associate-protein-engineering/