# Scientist, Mass Spectrometry at Axiom Bio

- Company: Axiom Bio
- What the company does: Axiom provides frontier intelligence for human drug toxicity, helping scientists reduce unexpected toxicity earlier and develop safer medicines with less animal testing. Backed by Amplify Partners.
- Company website: https://axi.om
- Type: Startups
- Level: Mid level
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-11-01
- Apply by: 2026-12-16
- Apply: https://jobs.ashbyhq.com/axiombio/ca72eb92-080b-40b0-8d8c-c0e142280d0a?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/axiom-bio-scientist-mass-spectrometry/

## About the role

Own Axiom’s LC-MS/MS operations across targeted and untargeted workflows, including chromatography, UV detection, mass spectrometry, and supporting equipment. Develop and run reactive-metabolism assays to identify drug metabolites and trapped reactive intermediates, using isotope-labeled controls to verify signals and support structural interpretation. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- LC-MS/MS operation and method development, including UHPLC, UV detection, high-resolution MS, and fragmentation methods
- Instrument troubleshooting, preventive maintenance, vacuum systems, nitrogen generators, and sample preparation equipment
- Reactive-metabolite trapping, metabolic incubations, stable-isotope labeling, and metabolite identification
- Targeted and untargeted metabolomics, including extraction, chromatographic separation, and analysis of complex biological matrices
- Proteomics sample preparation, protein digestion, peptide separation, and LC-MS/MS acquisition
- Assay development and qualification, calibration, internal standards, matrix effects, recovery, carryover, and measurement uncertainty


Source: 1752vc Careers, https://www.1752.vc/careers/jobs/axiom-bio-scientist-mass-spectrometry/