# Principal Scientist / Associate Director, Developability & Protein Sciences at Cartography Biosciences

- Company: Cartography Biosciences
- What the company does: About Cartography Biosciences Cartography Biosciences is advancing a differentiated oncology pipeline of antibody-based therapies designed to target tumors with unprecedented precision. Backed by a16z.
- Company website: https://cartography.bio
- Type: Startups
- Level: Principal and up
- Location: South San Francisco, CA
- Work setup: On-site
- Pay: $175K to $190K base salary per year (USD)
- Posted: 2026-10-15
- Apply by: 2026-11-29
- Apply: https://ats.rippling.com/cartography-biosciences/jobs/47c99e11-605d-43a8-8dc6-ac1495d5365c?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/cartography-biosciences-principal-scientist-associate-director-developability-an/

## About the role

We are looking for a Principal Scientist or Associate Director to lead developability and protein sciences for our bispecific and multispecific antibody programs, including T-cell engagers. You will own the biophysical and developability screening that informs lead selection, along with the expression and purification that supplies it, working in house and with external partners. You will manage and grow a small team of scientists and play a leading role on cross-functional therapeutic program teams. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Deliver developability and biophysical data for therapeutic programs as candidates advance from hit screening through lead optimization to development candidate nomination
- Integrate in silico biophysical property assessment (e.g. sequence liabilities, surface patch analysis, aggregation propensity) with experimental data to prioritize and engineer candidates
- Characterize advanced leads and development candidates in depth through stress and forced degradation studies, PTM mapping (e.g. peptide mapping LC-MS), and early formulation development
- Help define and own the developability criteria at each program decision gate, and apply them consistently across programs
- Expand the throughput, robustness, and technical scope of our protein analytics capabilities to support AI/ML-driven antibody engineering
- Oversee research-stage protein production from 1 mL to 10 L scale, in house and through external partners, run as a service with clear intake, prioritization, turnaround, and quality acceptance of incoming material

Tags: Development

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/cartography-biosciences-principal-scientist-associate-director-developability-an/