# Director, HEOR – Orexin Franchise at Centessa Pharmaceuticals

- Company: Centessa Pharmaceuticals
- What the company does: Patient-Centric Mission. Asset-Centric Approach. We’re pursuing our Orexin Receptor 2 Agonist Program to bring potentially transformative treatment options to patients with sleep-wake, neurological, neurodegenerative and neuropsychiatric disorders.... Backed by Foresite Capital.
- Company website: https://centessa.com
- Type: Startups
- Level: Principal and up
- Location: Boston, MA
- Work setup: On-site
- Pay: $180K to $260K base salary per year (USD)
- Posted: 2026-09-18
- Apply by: 2026-11-02
- Apply: https://job-boards.greenhouse.io/centessapharmaceuticalsinc/jobs/6199474004?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/centessa-pharmaceuticals-director-heor-orexin-franchise/

## About the role

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Advanced degree (PhD, PharmD, or Master's) in health economics and outcomes research, pharmacoepidemiology, epidemiology, public health, health services research, health policy, pharmacy, or a related field
- 10+ years of relevant experience in health economics, outcomes research, epidemiology, or related disciplines within the pharmaceutical, biotechnology, healthcare, academic, or consulting sectors
- Experience designing and conducting studies using healthcare databases and other real-world data sources (claims, EHR, registries)
- Experience developing PRO strategies and/or RWE designs such as external or synthetic control arms
- Strong knowledge of the regulatory and payer landscape, including experience designing evidence strategies that meet payer and regulatory requirements for novel therapies
- Strong project management skills, with the ability to manage multiple projects and priorities in a matrixed organization

Tags: Medical Affairs

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/centessa-pharmaceuticals-director-heor-orexin-franchise/