# Executive Medical Director at Denali Therapeutics

- Company: Denali Therapeutics
- What the company does: Denali Therapeutics brings the power of biotherapeutics to the whole body, including the brain. We discover, develop and deliver medicines for people living with serious diseases. Backed by GV.
- Company website: https://www.denalitherapeutics.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-08-25
- Apply by: 2026-10-09
- Apply: https://dnli.wd1.myworkdayjobs.com/en-US/Development/job/South-San-Francisco/Executive-Medical-Director_R-1591
- Page: https://www.1752.vc/careers/jobs/denali-therapeutics-executive-medical-director/

## About the role

Provides medical oversight of clinical trial design, ensuring scientific rigor, endpoint defensibility, and alignment with regulatory expectations Establishes clinical development standards, frameworks, and best practices across programs.

## What they're looking for

- Required
- M.D. or M.D./Ph.D. with formal training in the areas of neurology, neuroscience, genetics, immunology, and/or rare disease
- Minimum 12 years of combined experience, with at least 7 years in the pharmaceutical or biotechnology industry in senior medical/clinical roles
- Typically 3 or more years in a people management role, with demonstrated success in talent development, performance management, and team building
- Deep expertise in clinical trial design, endpoint strategy, SAP development, regulatory interactions, and DSMB/IDMC processes
- Proven experience leading or contributing significantly to a pivotal trial data readout, including topline analysis, NDA/BLA regulatory submission, and external data disclosure