# Principal Scientist, Translational Medicine at Denali Therapeutics

- Company: Denali Therapeutics
- What the company does: Denali Therapeutics brings the power of biotherapeutics to the whole body, including the brain. We discover, develop and deliver medicines for people living with serious diseases. Backed by GV.
- Company website: https://www.denalitherapeutics.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-08-25
- Apply by: 2026-10-09
- Apply: https://dnli.wd1.myworkdayjobs.com/en-US/Development/job/South-San-Francisco/Principal-Scientist--Translational-Medicine_R-1611
- Page: https://www.1752.vc/careers/jobs/denali-therapeutics-principal-scientist-translational-medicine/

## About the role

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

## What they're looking for

- PhD in a relevant scientific discipline (e.g., biochemistry, neurobiology, molecular biology, pharmacology) with typically 10+ years of post-training industry and/or academic experience
- Demonstrated expertise in developing, executing, and interpreting complex biomarker assays in a clinical study setting
- Experience contributing to regulatory submissions (e.g., BLA, NDA, IND), particularly biomarker-related sections and health authority interactions
- Record of high-quality publications and/or public presentations in rare disease, translational research, or biomarkers
- Strong oral, written, and presentation communication skills across scientific and cross-functional audiences