# Senior Principal Scientist, Translational Medicine at Denali Therapeutics

- Company: Denali Therapeutics
- What the company does: Denali Therapeutics brings the power of biotherapeutics to the whole body, including the brain. We discover, develop and deliver medicines for people living with serious diseases. Backed by GV.
- Company website: https://www.denalitherapeutics.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-11-04
- Apply by: 2026-12-19
- Apply: https://dnli.wd1.myworkdayjobs.com/en-US/Development/job/South-San-Francisco/Senior-Principal-Scientist--Translational-Medicine_R-1712?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/denali-therapeutics-senior-principal-scientist-translational-medicine/

## About the role

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Lead complex, cross-functional, and external biomarker research programs within Translational Medicine
- Lead cross-functional teams that deliver therapeutic project team objectives
- Define biomarker strategies that generate clinical evidence of target engagement, pathway engagement, and disease-biomarker modulation, including surrogate or intermediate endpoints that support accelerated approval
- Direct the design, qualification, and implementation of biomarker assays in clinically relevant biosamples
- Author biomarker strategy and data packages for BLAs and other regulatory submissions, including briefing documents and health authority responses
- Interpret complex data sets and communicate results to scientific, clinical, and leadership audiences


Source: 1752vc Careers, https://www.1752.vc/careers/jobs/denali-therapeutics-senior-principal-scientist-translational-medicine/