# Director/Senior Director, Computational Chemistry at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Principal and up
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $176K to $294K base salary per year (USD)
- Posted: 2026-08-18
- Apply by: 2026-10-14
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8725940002?gh_jid=8725940002
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-director-senior-director-computational-chemistry/

## About the role

FL111 is seeking a Director/Senior Director, Computational Chemistry to spearhead the design and optimization of heterobifunctional small molecules. This leader will work closely with medicinal chemists, structural biologists, and project teams to develop and apply computational tools to guide molecular design decisions across the design–build–test–learn cycle. The successful candidate will drive molecular ideation, property optimization, and compound prioritization across the portfolio.

## What they're looking for

- PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, or a related discipline, with 10+ years of relevant industry experience, including demonstrated scientific leadership and people management experience
- Deep expertise in computational medicinal chemistry and structure-based drug design in the binary and ternary settings, with a track record of driving impactful decisions across multiple drug discovery programs
- Demonstrated ability to drive and evaluate real, synthetically actionable molecular designs and to mentor and develop scientists to do the same
- Experience using cheminformatics tools for compound design, analysis and prioritization
- Proven scientific leadership and communication skills: demonstrated ability to build, lead, and inspire interdisciplinary teams and influence senior stakeholders
- Prior experience working on heterobifunctional small molecules (e.g., PROTACs) is preferred

Tags: Research/Discovery

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/flagship-pioneering-director-senior-director-computational-chemistry/