# Principal Data Engineer at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Principal and up
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $179K to $236K base salary per year (USD)
- Posted: 2026-10-27
- Apply by: 2026-12-11
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8919733002?gh_jid=8919733002&utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-principal-data-engineer/

## About the role

We are seeking a Principal Data Engineer to lead the architecture and evolution of the data platform underpinning our human genetics, multi-omics, and high-content imaging programs. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- 10+ years building and operating production data infrastructure, with a track record of architecting and owning platforms end to end
- Deep AWS expertise: S3, IAM, EC2, Batch, Lambda, and Spark (EMR or equivalent). Experience as technical owner of production cloud environments, including multi-account architecture and cross-account access
- Strong Python and SQL, with a background in production-grade pipeline development
- Production experience with workflow orchestration (Nextflow, Airflow, Temporal, Step Functions, Redun, or similar) and the judgement to evaluate and select among them
- Infrastructure as code (CloudFormation/CDK), CI/CD, containers, and observability. DevOps is a core competency for this role
- Data modelling and warehouse or lakehouse design, including metadata management, lineage, and data quality practice

Tags: Computational & Data Sciences

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/flagship-pioneering-principal-data-engineer/