# Principal Scientist, Evolutionary Search & Autonomous Discovery at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Principal and up
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $208K to $286K base salary per year (USD)
- Posted: 2026-09-25
- Apply by: 2026-11-09
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8843913002?gh_jid=8843913002
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-principal-scientist-evolutionary-search-and-autonomous-disco/

## About the role

Pioneering Intelligence is building an autonomous system capable of exploring large scientific and computational search spaces. A central challenge in this effort is designing algorithms that can generate, evaluate, refine, and recombine candidate solutions over many iterative cycles, continuously improving their performance while maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms.

## What they're looking for

- Demonstrated ability to design novel algorithms from first principles and bring them to working, validated implementations
- Strong software engineering skills and comfort running computational experiments at scale (parallel/distributed execution of many model evaluations)
- A record of scientific leadership recognized by the field — for example, first-author work at top-tier venues (e.g., NeurIPS, ICML, ICLR), influential publications, or widely adopted open-source tools
- Experience applying these methods to biological, scientific, or other mechanistic-modeling domains is highly desirable
- Ability to operate as a senior IC: setting technical direction, collaborating across research and engineering, and mentoring junior colleagues

Tags: Artificial Intelligence