# Principal Scientist, Structural Biology / Protein Biophysics at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Principal and up
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $163K to $215K base salary per year (USD)
- Posted: 2026-11-04
- Apply by: 2026-12-19
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8928133002?gh_jid=8928133002&utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-principal-scientist-structural-biology-protein-biophysics/

## About the role

We are seeking a motivated, highly collaborative, and technically versatile Principal Scientist to help build FL132’s amyloid research platform from the ground up. This is a hands-on role at the interface of protein biophysics, chemical biology, structural biology, and drug discovery: producing assay-grade amyloid proteins, developing and qualifying rigorous aggregation and structural assays, and characterizing amyloid aggregates to advance therapies for amyloidogenic diseases. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- PhD. in structural biology, chemical biology, biochemistry, biophysics, physical chemistry, or a related field, with 8+ years of relevant industry or postdoctoral experience
- Hands-on recombinant protein expression, purification, and QC ideally with intrinsically disordered or aggregation-prone proteins
- Deep expertise with kinetic assays of protein aggregation, familiarity with global kinetic-fitting of resulting data
- Familiarity with amyloid aggregation mechanisms and strain/seeding biology, and with cofactor/inducer systems
- Motivated team-player and effective independent contributor with strong organizational and written/verbal communication skills

Tags: Research/Discovery

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/flagship-pioneering-principal-scientist-structural-biology-protein-biophysics/