# Senior Scientist, LNP Formulations at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Senior
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $126K to $182K base salary per year (USD)
- Posted: 2026-11-03
- Apply by: 2026-12-18
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8925157002?gh_jid=8925157002&utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-senior-scientist-lnp-formulations/

## About the role

We are seeking a highly motivated Senior Scientist II with deep expertise in lipid chemistry to drive the design of novel ionizable lipids and the next generation of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on the rational design and synthesis of new ionizable lipids, the design of optimized LNP molar compositions, and the preparation of LNP formulations to screen and benchmark those new lipids. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- PhD. in Organic Chemistry, Medicinal Chemistry, Chemical Biology, Pharmaceutical Sciences or a related field, with 5+ years of relevant industry experience, or M.S. with 8+ years of experience
- Strong background in multi-step organic synthesis, purification and structural characterization, ideally of lipids, amphiphiles or other delivery materials
- Hands-on experience with LNP formulation (e.g., microfluidic mixing, nanoprecipitation) and an understanding of how lipid structure and molar composition drive potency, stability and tolerability
- Experience designing and running formulation screens, including characterization by DLS, encapsulation assays and pKa determination
- Experience with nucleic acid delivery (mRNA, DNA, siRNA) is highly preferred
- Familiarity with lipid analytics (NMR, LC-MS, HPLC-CAD/ELSD) and with computational or data-driven approaches to lipid design is a plus

Tags: Chemistry

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/flagship-pioneering-senior-scientist-lnp-formulations/