# Senior Scientist, Protein Engineering at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Senior
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $126K to $182K base salary per year (USD)
- Posted: 2026-10-02
- Apply by: 2026-11-16
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8863732002?gh_jid=8863732002&utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-senior-scientist-protein-engineering-2/

## About the role

We are seeking a motivated and highly collaborative Senior Scientist to join FL129's growing team of experimental and computational scientists building a novel platform technology. The successful candidate will design, construct, and functionally interrogate large protein variant libraries — linking variant genotype to measured phenotype at scale — and will help translate those readouts into data products that drive the platform. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Ph.D. in molecular biology, biochemistry, protein engineering, or a related field, with 5+ years of industry or postdoctoral experience
- Hands-on expertise in library-scale molecular cloning — site-saturation or degenerate-codon mutagenesis, high-efficiency transformation, and managing library complexity, variant coverage, and bottlenecking
- Experience with a protein display or genotype-to-phenotype linkage system (e.g., yeast surface display, mammalian display, or phage display)
- Experience with fluorescence-activated cell sorting (FACS), including selection strategy and sort-gate design for quantitative variant enrichment
- Experience with next-generation sequencing readouts for variant-level analysis (e.g., Illumina amplicon sequencing)
- A motivated team-player and independent force-of-nature with strong organizational and written/verbal communication skills

Tags: Biological Engineering

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/flagship-pioneering-senior-scientist-protein-engineering-2/