# Senior Scientist, Small Molecule Screening at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Senior
- Location: Cambridge, MA USA
- Work setup: On-site
- Pay: $126K to $182K base salary per year (USD)
- Posted: 2026-09-24
- Apply by: 2026-11-08
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8843024002?gh_jid=8843024002
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-senior-scientist-small-molecule-screening/

## About the role

We are seeking a motivated and highly collaborative Senior Scientist to join FL129’s growing team of experimental and computational scientists to build a novel platform technology. The successful candidate will have a strong track record of scientific and technical innovation in DNA-encoded library (DEL) design, synthesis, and affinity-based selection.

## What they're looking for

- Ph.D. in organic chemistry, medicinal chemistry, chemical biology, or a similar field with 5+ years of industry or postdoctoral experience
- End-to-end experience with DNA-encoded library (DEL) screening, from library design and synthesis through affinity selection, next-generation sequencing, and hit deconvolution
- Hands-on expertise in DNA-compatible chemistry, including split-and-pool combinatorial synthesis, building-block validation, and development or adaptation of reactions to on-DNA conditions
- Experience with encoding and tagging strategies, including barcode design and enzymatic ligation, and with analytical quality control of library synthesis (e.g., LC-MS)
- Experience with affinity selection formats and their controls, including immobilized and solution-phase targets, matrix and negative selections, and DNA-encoded positive controls
- Experience with on-DNA and off-DNA hit validation, including resynthesis and biochemical/biophysical assays to confirm and quantitate the bioactivity of screening hits

Tags: Research/Discovery