# Sr. Director, Clinical Operations at Flagship Pioneering

- Company: Flagship Pioneering
- What the company does: Pioneering Partnerships Latest News.
- Company website: https://www.flagshippioneering.com
- Type: VC firms
- Level: Principal and up
- Location: Somerville, MA USA
- Work setup: On-site
- Pay: $213K to $280K base salary per year (USD)
- Posted: 2026-09-24
- Apply by: 2026-11-08
- Apply: https://boards.greenhouse.io/flagshippioneeringinc/jobs/8830615002?gh_jid=8830615002
- Page: https://www.1752.vc/careers/jobs/flagship-pioneering-sr-director-clinical-operations/

## About the role

Metaphore Biotechnologies is seeking a Senior Director of Clinical Operations to lead the hands-on execution of early clinical development activities for the company’s first-in-human program. Reporting to the Chief Medical Officer, this is a senior individual-contributor role with broad ownership and visibility across the organization.

## What they're looking for

- BS/MS/PhD degree in a scientific, healthcare, or related discipline, an advanced degree is preferred
- 10+ years of progressive clinical operations experience in the biotechnology or pharmaceutical industry
- Direct experience leading first-in-human or Phase 1 studies from operational planning and vendor selection through regulatory and ethics submissions, site activation, first-participant-in, and ongoing execution
- Strong working knowledge of CRO and vendor selection and oversight, site strategy, global study start-up, and operational planning
- Demonstrated experience managing study budgets, vendor contracts, scopes of work, change orders, timelines, and forecasts
- Experience reviewing clinical protocols and translating study designs into executable operational plans

Tags: G&A