# Principal Scientist and Group Leader, Antibody Engineering at Genentech

- Company: Genentech
- What the company does: Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
- Company website: https://gene.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-10-02
- Apply by: 2026-11-16
- Apply: https://roche.wd3.myworkdayjobs.com/en-US/ROG-A2O-GENE/job/South-San-Francisco/Principal-Scientist-and-Group-Leader--Antibody-Engineering_202609-124559?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/genentech-principal-scientist-and-group-leader-antibody-engineering/

## About the role

Genentech’s Department of Antibody Engineering is seeking a visionary Principal Scientist to lead a high-impact laboratory team at the forefront of biotherapeutic innovation. In this role, you will pioneer breakthrough protein technologies that seamlessly bridge molecular developability with optimized biological function to advance our biologics pipeline . Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Direct and manage a bench-focused laboratory team, fostering technical growth, innovative research, and effective execution
- Advance internal technological capabilities by developing novel methods and predictive assays to de-risk emerging therapeutic formats
- Define molecular requirements for therapeutic projects and lead cross-functional teams to identify and advance next-generation clinical candidates
- Drive platform innovation across emerging biotherapeutic mechanisms, potentially including induced proximity, receptor agonism, targeted therapeutics, or antibody-drug conjugates (ADCs)
- Cultivate an inclusive, high-performing lab culture built on curiosity, scientific rigor, and open communication
- PhD in biochemistry, chemical biology, structural biology, or a related field. We encourage applications from candidates with extensive prior experience as well as those coming directly from postdoctoral positions


Source: 1752vc Careers, https://www.1752.vc/careers/jobs/genentech-principal-scientist-and-group-leader-antibody-engineering/