# Principal Scientist, Structural Biology at Genentech

- Company: Genentech
- What the company does: Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
- Company website: https://gene.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-09-08
- Apply by: 2026-10-23
- Apply: https://roche.wd3.myworkdayjobs.com/en-US/ROG-A2O-GENE/job/South-San-Francisco/Principal-Scientist--Structural-Biology_202608-122144
- Page: https://www.1752.vc/careers/jobs/genentech-principal-scientist-structural-biology/

## About the role

As a Principal Scientist in Structural Biology, you will help drive drug discovery initiatives by uncovering the structural and dynamic mechanisms of therapeutic target proteins. Working in a highly interdisciplinary environment, you will integrate structural data, advanced computational modeling, and biophysical insights to enable the discovery of life-changing medicines. Lead structural biology strategy and execution within multi-disciplinary drug discovery project teams, offering actionable structural insights.

## What they're looking for

- You hold a Ph.D. or equivalent in Biochemistry, Structural Biology, Biophysics, Computational Biology, or a related scientific discipline
- You have a minimum of 3 years of relevant post-doctoral experience in industry, academia or a research organization
- An expert in molecular modeling techniques such as molecular dynamics simulation, structural ensemble modeling, ensemble docking and/or related techniques
- You have demonstrated expertise in biomolecular structure determination via cryoEM or X-ray crystallography
- You have a proven track record leveraging insights into protein or protein-ligand molecular dynamics to enable, accelerate, and/or improve target identification, pocket discovery, binder discovery, ligand optimization and/or other steps of drug discovery
- A collaborative leader who knows how to guide, inspire and motivate colleagues and teams based on scientific merit and mutual respect, rather than organizational hierarchy