# Principal Scientist - Translational Medicine, Oncology at Genentech

- Company: Genentech
- What the company does: Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
- Company website: https://gene.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-09-29
- Apply by: 2026-11-13
- Apply: https://roche.wd3.myworkdayjobs.com/en-US/ROG-A2O-GENE/job/South-San-Francisco/Principal-Scientist---Translational-Medicine--Oncology_202609-123996
- Page: https://www.1752.vc/careers/jobs/genentech-principal-scientist-translational-medicine-oncology/

## About the role

As a Principal Scientist in Translational Medicine Oncology, you will serve as a vital scientific anchor bridging discovery research and clinical development. You will lead biomarker discovery and translational strategy for innovative oncology clinical pipelines, working directly on early- to late-stage clinical programs. In this role, you will: This role is based in South San Francisco and offers a hybrid schedule working 3 days per week on campus.

## What they're looking for

- Design, implement, and drive end-to-end pharmacodynamic and predictive biomarker strategies across first-in-human through registrational clinical studies
- Champion hypothesis-driven translational research to identify novel biomarkers of therapeutic response, mechanisms of clinical resistance, and tumor microenvironment dynamics
- Integrate and leverage high-dimensional data—including multi-omic profiling, spatial biology, single-cell platforms, and functional immune assays—in partnership with computational scientists and AI-driven platforms
- Lead the authoring, review, and strategic integration of biomarker and translational sections within clinical trial protocols, regulatory submissions, clinical study reports, and investigator brochures
- Partner cross-functionally across Research, Clinical Development, Clinical Pharmacology, Companion Diagnostics, Biostatistics, and Clinical Operations to ensure seamless scientific alignment
- Partner with Operations team to provide scientific leadership and strategic guidance for trial design, implementation, and conduct