# Principal Scientist – Translational Medicine (Tumor Microenvironment) at Genentech

- Company: Genentech
- What the company does: Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
- Company website: https://gene.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Pay: $142K to $263K base salary per year (USD)
- Posted: 2026-10-26
- Apply by: 2026-12-10
- Apply: https://roche.wd3.myworkdayjobs.com/en-US/ROG-A2O-GENE/job/South-San-Francisco/Principal-Scientist---Translational-Medicine--Tumor-Microenvironment-_202610-127522-1?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/genentech-principal-scientist-translational-medicine-tumor-microenvironment/

## About the role

This role also includes developing and leading hypothesis-driven translational research focused on identifying and developing novel biomarkers of therapeutic response and resistance, as well as uncovering disease-specific mechanistic insights. The candidate will collaborate closely on cross-functional biomarker efforts, working with colleagues across Research, Clinical Development, Diagnostics, Computational Science, Clinical Pharmacology, Regulatory, and Biostatistics. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- PhD, MD, or MD/PhD in molecular biology, cancer biology, immunology, computational biology, bioinformatics, or a related field
- Demonstrated scientific excellence through impactful graduate or postdoctoral research, including first-author publications in high-quality peer-reviewed journals
- 3-5 years of experience with translational research approaches including molecular profiling, multi-omic analyses, spatial biology, single-cell technologies, and/or functional immune assays is preferred
- Interest in leveraging innovative computational approaches, including emerging AI-enabled and agentic AI tools, to support biomarker discovery, translational insight generation, and data interpretation is a plus
- Strong scientific curiosity with the ability to independently develop hypotheses and translate complex biological observations into mechanistic insight
- Excellent written and verbal communication skills, with the ability to communicate complex scientific concepts to multidisciplinary audiences


Source: 1752vc Careers, https://www.1752.vc/careers/jobs/genentech-principal-scientist-translational-medicine-tumor-microenvironment/