# Principal / Senior Principal Scientist- Investigative Toxicology at Genentech

- Company: Genentech
- What the company does: Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
- Company website: https://gene.com
- Type: Startups
- Level: Principal and up
- Location: South San Francisco
- Work setup: On-site
- Posted: 2026-09-21
- Apply by: 2026-11-05
- Apply: https://roche.wd3.myworkdayjobs.com/en-US/ROG-A2O-GENE/job/South-San-Francisco/Senior-Principal-Scientist---Drug-Development_202609-123267-1
- Page: https://www.1752.vc/careers/jobs/genentech-principal-senior-principal-scientist-investigative-toxicology/

## About the role

We are seeking an experienced and forward-thinking to join our team as an individual contributor. In this role, you will be responsible for driving the strategy, development, and implementation of predictive and mechanistic safety capabilities specifically tailored to support our Neuroscience and Cardiovascular, Renal, and Metabolic (CVRM) portfolios.

## What they're looking for

- Serve as the primary Investigative Toxicology subject matter expert and representative on discovery and early development project teams across the Neuroscience and CVRM portfolios
- Apply a deep working knowledge of drug discovery/development workflows to identify rate-limiting safety liabilities early, define critical path questions, and influence candidate selection
- Partner with Project Team Toxicologists, Discovery Scientists, and Pathologists to guide nonclinical safety strategies and mechanistic de-risking plans
- Operate effectively in ambiguous, newly established scientific areas by identifying technological gaps and designing innovative solutions to characterize on-target and exaggerated pharmacology liabilities
- Drive the strategic identification, validation, and implementation of next-generation capability needs for Neuro and CVRM safety assessment
- Act as the lead scientific strategist leveraging matrixed support from Investigative Toxicology wet-lab members to design, oversee, and interpret complex experimental studies