# Scientist 3, CVRM Discovery Research Biology at Genentech

- Company: Genentech
- What the company does: Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
- Company website: https://gene.com
- Type: Startups
- Level: Mid level
- Location: South San Francisco
- Work setup: On-site
- Pay: $103K to $192K base salary per year (USD)
- Posted: 2026-10-18
- Apply by: 2026-12-02
- Apply: https://roche.wd3.myworkdayjobs.com/en-US/ROG-A2O-GENE/job/South-San-Francisco/Scientist-3--CVRM-Discovery-Research-Biology_202610-125763?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/genentech-scientist-3-cvrm-discovery-research-biology/

## About the role

The Cardiovascular, Renal and Metabolism (CVRM) Research Biology group within Genentech Research and Early Development (gRED) is seeking an innovative and highly motivated Scientist 3 to advance our extra-hepatic, cell- and tissue-selective drug delivery platforms. In this laboratory-based role, you will lead the biological discovery and validation of novel cell-surface receptors to enable targeted delivery of nucleic acid therapeutics (such as siRNAs and ASOs). Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Develop and execute an overarching biological strategy to identify, prioritize, and validate cell-surface receptors capable of mediating selective nucleic acid delivery to CVRM-relevant tissues
- Establish, culture, and characterize physiologically relevant in vitro and ex vivo cellular systems (including striated muscle) for targeted-delivery evaluation
- Design and implement quantitative mechanistic assays to assess ligand-receptor binding, occupancy, internalization kinetics, intracellular trafficking, and endosomal escape
- Evaluate novel targeting ligands and bioconjugates (such as antibody- or peptide-oligonucleotide conjugates) for functional cargo delivery, downstream pharmacodynamics, and target gene modulation
- Apply genetic and molecular perturbation tools, including CRISPR and RNAi, alongside biochemical methods to establish definitive receptor dependency and mechanism of action
- Design and execute preclinical in vivo biodistribution and proof-of-concept pharmacology studies to demonstrate disease-modifying therapeutic potential


Source: 1752vc Careers, https://www.1752.vc/careers/jobs/genentech-scientist-3-cvrm-discovery-research-biology/