# Scientist/Sr. Scientist, Computational Chemistry at General Proximity

- Company: General Proximity
- What the company does: General Proximity pioneers next-generation medicines by controlling biological processes through proximity. Redefining the future of medicine for all humankind. Backed by Y Combinator and Felicis.
- Company website: https://www.generalproximity.bio/
- Type: Startups
- Level: Senior
- Location: San Francisco, CA
- Work setup: On-site
- Posted: 2026-07-29
- Apply by: 2026-10-08
- Apply: https://job-boards.greenhouse.io/generalproximity/jobs/6130243004
- Page: https://www.1752.vc/careers/jobs/general-proximity-scientist-sr-scientist-computational-chemistry/

## About the role

We are seeking an exceptional computational chemist to support our computational chemistry, cheminformatics, and molecular design efforts. This role will help drive small-molecule drug discovery programs by providing practical modeling support, applying modern computational workflows, and using the cheminformatics and AI-enabled tools that empower medicinal chemists and project teams.

## What they're looking for

- PhD in Computational Chemistry, Medicinal Chemistry, Chemical Physics, Biophysics, Cheminformatics, Physical Organic Chemistry, or a related discipline
- A minimum of 3 years of relevant experience in pharma, biotech, or a drug discovery-focused research environment
- Track record of using computational chemistry to impact small-molecule drug discovery programs, ideally through hit-to-lead or lead optimization
- Hands-on expertise in structure-based drug design, ligand-based design, docking, molecular dynamics, virtual screening, QSAR, FEP/free-energy methods, pharmacophore modeling, and multi-parameter optimization
- Strong working knowledge of medicinal chemistry principles, SAR interpretation, physicochemical property optimization, ADME/PK concepts, and developability considerations
- Practical experience with cheminformatics platforms, chemical databases, chemical data curation, compound registration systems, and project-facing visualization tools

Tags: Chemistry Team