# Principal Computational Biologist at Gordian Biotechnology

- Company: Gordian Biotechnology
- What the company does: Are you ready to own the strategy behind how Gordian turns large-scale in vivo perturbation screens into a prioritized, translatable pipeline of therapeutic targets across chronic and age-related disease, and to help build sophisticated analytical frameworks... Backed by Stanford.
- Company website: https://gordian.bio
- Type: Startups
- Level: Principal and up
- Location: South San Francisco, CA
- Work setup: On-site
- Pay: $170K to $230K base salary per year (USD)
- Posted: 2026-09-25
- Apply by: 2026-11-09
- Apply: https://ats.rippling.com/gordian-biotechnology/jobs/24cbe2bc-6d6d-4ec9-8b84-363b9d5f3a01
- Page: https://www.1752.vc/careers/jobs/gordian-biotechnology-principal-computational-biologist/

## About the role

Gordian has generated in vivo perturbation data spanning over 1000 targets across Obesity, Heart Failure, Pulmonary Fibrosis, Osteoarthritis, MASH, and Chronic Kidney Disease (CKD), while partnering with external collaborators to build the most comprehensive knowledge graph of disease-relevant, translatable therapeutics in this space. As a Principal Computational Biologist, you go beyond executing individual screen analyses: you pioneer how Gordian strategizes around perturbation data.

## What they're looking for

- Experience with pooled perturbation and CRISPR screening data specifically
- Experience with spatial transcriptomics data (10X Xenium, Visium, etc)
- Experience with preclinical models for validation with functional readouts (e.g., human explants, organoids, etc.)

Tags: Data

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/gordian-biotechnology-principal-computational-biologist/