# Staff Security Engineer at Guardant Health

- Company: Guardant Health
- What the company does: Guardant Health is a leading precision medicine company focused on transforming patient care and conquering cancer with data. Backed by Khosla, Lightspeed and Sequoia.
- Company website: https://guardanthealth.com/
- Type: Startups
- Level: Senior
- Location: Remote - Open Position (USA)
- Work setup: Remote
- Pay: $134K to $184K base salary per year (USD)
- Posted: 2026-10-26
- Apply by: 2026-12-10
- Apply: https://gh.wd1.myworkdayjobs.com/en-US/gh/job/Remote---Open-Position-USA/Staff-Security-Engineer_R-101298-1?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/guardant-health-staff-security-engineer/

## About the role

The Staff Security Engineer, reporting to the Associate Director of Security Engineering, will be responsible for strengthening Guardant Health’s ability to detect, investigate, and respond to threats. This role focuses on detection engineering, threat intelligence, security automation, and incident response, with an emphasis on infrastructure, cloud, endpoint, and identity security. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- 8+ years of experience in security engineering, security operations, detection engineering, or incident response
- Strong hands-on experience developing, testing, and tuning SIEM and EDR detections across multiple environments
- Strong background in threat detection and incident response within a SOC environment
- Experience owning open source threat intelligence platforms such as MISP, Yeti, and OpenCTI
- Demonstrated ability to improve alert quality, reduce false positives, and incorporate business context into detection and response decisions
- Experience working with external MDR providers, managed SOCs, or SIEM service partners to improve detection content, investigations, escalations, and response outcomes


Source: 1752vc Careers, https://www.1752.vc/careers/jobs/guardant-health-staff-security-engineer/