# Principal Clinical Engineer – AI Performance & Investigations at HeartFlow

- Company: HeartFlow
- What the company does: Heartflow’s vision is to transform CAD from the leading cause of death into a disease that can be managed for life.
- Company website: https://www.heartflow.com
- Type: Startups (AI role)
- Level: Principal and up
- Location: San Francisco, California
- Work setup: On-site
- Pay: $188K to $240K base salary per year (USD)
- Posted: 2026-10-16
- Apply by: 2026-11-30
- Apply: https://job-boards.greenhouse.io/heartflowinc/jobs/6227786004?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/heartflow-principal-clinical-engineer-ai-performance-and-investigations/

## About the role

Heartflow is a medical technology company advancing the diagnosis and management of coronary artery disease, the #1 cause of death worldwide, using cutting-edge technology. The flagship product—an AI-driven, non-invasive cardiac test supported by the ACC/AHA Chest Pain Guidelines called the Heartflow FFR CT Analysis—provides a color-coded, 3D model of a patient’s coronary arteries indicating the impact blockages have on blood flow to the heart. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- 12+ years of experience in medical devices and/or regulated imaging products, with substantial time in engineering, investigation, or post-market quality roles
- Direct, hands-on experience with coronary CT, including CT angiography (CCTA), coronary plaque characterization, or atherosclerosis imaging
- Background as an R&D, Systems, or Quality Engineer, or in a clinical role, working with imaging medical devices
- Demonstrated experience leading complex, cross-functional technical investigations through to root cause and documented conclusion
- Working knowledge of complaint handling, MDR/vigilance reporting, CAPA, and risk management requirements (21 CFR Parts 803 and 820, ISO 13485, ISO 14971, EU MDR)
- Experience investigating issues in software or SaMD products, ideally in AI/ML-based devices, with working familiarity with the software lifecycle and anomaly management (IEC 62304)

Tags: Quality

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/heartflow-principal-clinical-engineer-ai-performance-and-investigations/