# Senior Principal Research Scientist, Computational Chemistry at Ideaya Biosciences

- Company: Ideaya Biosciences
- What the company does: Discover IDEAYA Biosciences' precision oncology approach targeting cancer vulnerabilities to develop transformative therapies for hard-to-treat cancers. Backed by GV.
- Company website: https://www.ideayabio.com
- Type: Startups (AI role)
- Level: Principal and up
- Location: South San Francisco HQ
- Work setup: On-site
- Pay: $196K to $242K base salary per year (USD)
- Posted: 2026-09-09
- Apply by: 2026-10-24
- Apply: https://ideayabio.wd501.myworkdayjobs.com/en-US/External/job/South-San-Francisco-HQ/Senior-Principal-Research-Scientist--Computational-Chemistry_2025-BF-213-001
- Page: https://www.1752.vc/careers/jobs/ideaya-biosciences-senior-principal-research-scientist-computational-chemistry/

## About the role

We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant pharmaceutical industry experience to join our multidisciplinary small molecule drug discovery organization. This is a senior individual contributor role for a highly experienced computational chemist with a strong track record of advancing pharmaceutical discovery programs through hands-on scientific impact.

## What they're looking for

- PhD in Computational Chemistry or a related discipline with 9+ years of pharmaceutical or biotechnology industry experience
- Strong understanding of small molecule drug discovery and medicinal chemistry principles
- Demonstrated expertise in structure-, ligand-, and fragment-based drug discovery
- Expertise in free energy perturbation, molecular dynamics, quantum mechanics, cheminformatics, and ligand affinity estimation methods
- Proven ability to independently deliver computational work that influences medicinal chemistry decisions and project outcomes
- Ability to manage priorities across multiple discovery programs