# Director of Nonclinical Safety, Cambridge, MA at Isomorphic Labs

- Company: Isomorphic Labs
- What the company does: Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines. Backed by GV.
- Company website: https://www.isomorphiclabs.com
- Type: Startups
- Level: Principal and up
- Location: Cambridge, MA
- Work setup: On-site
- Posted: 2026-08-17
- Apply by: 2026-10-08
- Apply: https://job-boards.greenhouse.io/isomorphiclabs/jobs/6142028004
- Page: https://www.1752.vc/careers/jobs/isomorphic-labs-director-of-nonclinical-safety-cambridge-ma/

## About the role

We are seeking a highly motivated and experienced Director of Nonclinical Safety to build our nonclinical safety function supporting programs in the Early Development phase.

## What they're looking for

- Lead, build, and scale the Nonclinical Safety function within an AI-first drug development environment
- Serve as the primary internal expert for post-IND nonclinical safety ensuring quality, consistency, and scalability as compounds transition into clinical trials
- Establish a critical data feedback loop: ensure high-quality data are fed back to computational teams to continuously train, validate, and refine our predictive nonclinical safety AI models
- Define and drive nonclinical safety and other translational strategies primarily for small molecule drug candidates in the Early Development phase across oncology and non-oncology indications
- Execute seamlessly on post-IND (NDA/MAA-enabling) nonclinical toxicology work, including chronic, reproductive, and carcinogenicity studies as needed
- Establish translational strategies by integrating exploratory nonclinical safety biomarkers and exposure-based modeling plans to predict and de-risk potential effects in humans

Tags: Clinical