# Director, Drug Substance Commercial Manufacturing at Kailera Therapeutics

- Company: Kailera Therapeutics
- What the company does: Kailera is a late clinical-stage biotechnology company advancing a diversified pipeline of GLP-1 therapies to provide options for people living with obesity. Backed by a16z.
- Company website: https://www.kailera.com
- Type: Startups
- Level: Principal and up
- Location: US-Remote
- Work setup: Remote
- Posted: 2026-11-02
- Apply by: 2026-12-17
- Apply: https://job-boards.greenhouse.io/kailera/jobs/5468453008?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/kailera-therapeutics-director-drug-substance-commercial-manufacturing/

## About the role

The Director, Drug Substance Commercial Manufacturing will own Drug Substance (DS) technology transfer, Manufacturing Science and Technology (MSAT), manufacturing oversight, and Operational Excellence (OpEx) for assigned CDMO sites in Kailera’s CDMO network. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Hands-on experience in MSAT or technical operations for commercial-stage DS manufacturing at CDMOs, including CPV, troubleshooting, and lifecycle change management
- Experience overseeing commercial DS manufacturing campaigns at external partners, including batch record review, deviation response, and recovery of at-risk supply
- Deep expertise in synthetic peptide DS manufacturing, including synthesis, purification, impurity control, scale-up, and process troubleshooting
- Demonstrated experience in technology transfer, process characterization, control strategy implementation, and PPQ
- Experience driving operational excellence and continuous improvement (yield, cycle time, cost, robustness) at CDMOs or external manufacturing sites
- Strong understanding of CDMO operating models, capabilities, capacity constraints, and commercial drivers, with experience establishing governance and managing external partner performance

Tags: Drug Substance

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/kailera-therapeutics-director-drug-substance-commercial-manufacturing/