# Principal Scientist, mRNA-tLNP Analytical Development at Kernal Biologics

- Company: Kernal Biologics
- What the company does: Kernal biologics is an onco-selective mRNA therapeutics company located in Cambridge, MA. Backed by Y Combinator.
- Company website: https://www.kernalbio.com/
- Type: Startups (AI role)
- Level: Principal and up
- Location: Boston, MA
- Work setup: On-site
- Posted: 2026-08-12
- Apply by: 2026-10-08
- Apply: https://job-boards.greenhouse.io/kernalbio/jobs/7859605003
- Page: https://www.1752.vc/careers/jobs/kernal-biologics-principal-scientist-mrna-tlnp-analytical-development/

## About the role

The Principal Scientist, Analytical Development at Kernal Biologics, will report to the Director of Drug Product Development and will lead the design, development, and execution of analytical methods to support the company’s mRNA platform for in vivo CAR-T programs.

## What they're looking for

- PhD (6+ years), MS (8+ years), or BS (12+ years) in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related field, with relevant industry experience
- Strategic understanding of characterization approaches for mRNA, LNPs, biologics, monoclonal antibodies, and related modalities and bioconjugations
- Experience providing technical oversight of CRO/CDMO analytical activities, including ICH-compliant stability programs and GMP testing
- Experience with cell-based potency assay development, qualification, and troubleshooting is highly desirable
- Strong knowledge of CMC regulatory expectations and analytical requirements for global regulatory submissions

Tags: R&D