# Associate Director or Director, PBPK & Biopharmaceutics Modeling at Kymera Therapeutics

- Company: Kymera Therapeutics
- What the company does: Kymera is inventing a new generation of small molecule medicines by tackling the root cause of disease with targeted protein degradation. Backed by Bessemer.
- Company website: http://www.kymeratx.com
- Type: Startups
- Level: Principal and up
- Location: Watertown, MA
- Work setup: On-site
- Pay: $160K to $275K base salary per year (USD)
- Posted: 2026-08-11
- Apply by: 2026-10-12
- Apply: https://www.kymeratx.com/careers-culture/working-at-kymera/?gh_jid=7854105003#open-positions
- Page: https://www.1752.vc/careers/jobs/kymera-therapeutics-associate-director-or-director-pbpk-and-biopharmaceutics-mod/

## About the role

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics.

## What they're looking for

- PhD or PharmD (or equivalent) in pharmaceutical sciences, DMPK, pharmacokinetics, chemical/biomedical engineering, or a related field, with 7+ years of hands-on PBPK/PBBM experience
- Deep understanding of ADME/DMPK and biopharmaceutics principles
- Significant hands-on GastroPlus experience (required), with a demonstrated ability to manage and deliver modeling work independently
- Experience modeling oral molecules with challenging developability profiles, including poorly soluble and/or permeable compounds and beyond-rule-of-five modalities such as targeted protein degraders (preferred)
- Proficiency in scripting for data handling, workflow automation, and model QC (e.g., R, Python, or MATLAB)
- Simcyp modeling experience (preferred)

Tags: Research