# Director, Head of Investigative Toxicology at Nurix AI

- Company: Nurix AI
- What the company does: AI agents that run your enterprise workflows and get measurably better over time. 150+ enterprises live in production across retail, insurance, and financial services. Backed by Accel and General Catalyst.
- Company website: https://www.nurix.ai/
- Type: Startups (AI role)
- Level: Principal and up
- Location: Brisbane, California
- Work setup: On-site
- Pay: $240K to $282K base salary per year (USD)
- Posted: 2026-11-05
- Apply by: 2026-12-20
- Apply: https://job-boards.greenhouse.io/nurix/jobs/8932672002?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/nurix-ai-director-head-of-investigative-toxicology/

## About the role

Nurix Therapeutics is seeking a Head of Investigative Toxicology to establish and lead our in-house in vitro toxicology testing capability. Reporting into the Preclinical Toxicology leadership team, this individual will build the assays, infrastructure, and mechanistic understanding needed to characterize target- and modality-related safety liabilities earlier in discovery, reducing reliance on external CROs for early screening and de-risking. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Design, establish, and validate an in-house in vitro toxicology testing platform, including assay selection, equipment procurement, protocol development, and standard operating procedures
- Develop and implement in vitro toxicology (primary and immortalized cell culture, hepatocyte and iPSC cardiomyocyte models) assays to screen for cytotoxicity and off-target liabilities
- Define the technical roadmap and prioritize which in vitro assays to bring in-house versus continue to source through CRO partners, balancing scientific value, cost, and speed
- Own day-to-day lab operations for the function, including equipment maintenance, vendor and reagent management, and data management systems
- Serve as the in vitro/investigative toxicology representative on discovery project teams, providing mechanistic insight into target and modality-related safety findings
- Design and interpret investigative studies to elucidate mechanisms of toxicity, including neosubstrate and off-target degradation risk relevant to targeted protein degrader molecules

Tags: Development & Preclinical

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/nurix-ai-director-head-of-investigative-toxicology/