# Principal Scientist/Associate Director, Downstream Process Development Formulation at Pivotal Life Sciences

- Company: Pivotal Life Sciences
- What the company does: Pivotal Life Sciences specializes in providing capital to innovative companies developing therapeutic products to address major unmet medical needs.
- Company website: https://pivotallifesciences.com
- Type: VC firms
- Level: Principal and up
- Location: San Diego, California
- Work setup: On-site
- Pay: $120K to $220K base salary per year (USD)
- Posted: 2026-06-09
- Apply by: 2026-10-08
- Apply: https://pivotal.bamboohr.com/careers/48
- Page: https://www.1752.vc/careers/jobs/pivotal-life-sciences-principal-scientist-associate-director-downstream-process/

## About the role

Job Title: Principal Scientist/Associate Director, Downstream Process Development Formulation About Us: A new stealth-mode biotech focused on in vivo gene editing.

## What they're looking for

- Demonstrated hands-on expertise in TFF process development for nanoparticle or biopharmaceutical applications, including membrane selection, process optimization, and scale-up
- Direct experience with SEC or chromatographic purification of lipid nanoparticles, liposomes, or related colloidal drug delivery systems
- Strong understanding of LNP formulation and characterization, including DLS, zeta potential, cryo-TEM, encapsulation efficiency, and particle stability assessment
- Experience defining CPPs and CQAs for downstream processes and contributing to process characterization and validation
- Proficiency with DOE-based experimental design and statistical analysis of process development data
- Excellent scientific communication skills, including technical report writing, SOPs, and presentation of data to cross-functional teams

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