# Scientist I/Scientist II, tLNP Formulation and Delivery at Profluent

- Company: Profluent
- What the company does: The next frontier is authoring new biology, and with AI, we have the power to write the future—creating solutions that transform medicine, agriculture, and beyond. Backed by Insight and Air Street.
- Company website: https://www.profluent.bio/
- Type: Startups (AI role)
- Level: Mid level
- Location: Emeryville, California, United States
- Work setup: On-site
- Posted: 2026-09-10
- Apply by: 2026-10-25
- Apply: https://job-boards.greenhouse.io/profluent/jobs/5421400008
- Page: https://www.1752.vc/careers/jobs/profluent-scientist-i-scientist-ii-tlnp-formulation-and-delivery/

## About the role

We are seeking a talented, self-motivated, and highly resourceful Scientist I / Scientist II to serve as a foundational scientist in establishing our next-generation Targeted Lipid Nanoparticle (tLNP) platform. This role is central to our strategy of achieving extrahepatic tissue tropism for next-generation genetic medicines.

## What they're looking for

- Hands-on experience with LNP assembly platforms (microfluidic/NanoAssemblr, T-junction, or ethanol injection) and surface bioconjugation techniques to functionalize nanoparticles with targeting moieties
- Demonstrated understanding and experience in shifting nanoparticle biodistribution/tropism through lipid compositional tweaking, molar ratio modification, or structural lipid alteration
- Hands-on proficiency in mammalian cell culture and running quantitative cell-based assays (Flow Cytometry/FACS, reporter assays, ELISAs)
- Understanding of systemic nanoparticle distribution, protein corona formation, vascular barriers, and in vivo study design principles. (Hands-on animal dosing or ex vivo tissue processing experience is not required)
- Entrepreneurial drive and organizational skills suited for building assays, protocols, and workflows in an early-stage, growing R&D environment

Tags: Biology