# Scientist II, Delivery for Large Gene Insertion at Profluent

- Company: Profluent
- What the company does: The next frontier is authoring new biology, and with AI, we have the power to write the future—creating solutions that transform medicine, agriculture, and beyond. Backed by Insight and Air Street.
- Company website: https://www.profluent.bio/
- Type: Startups (AI role)
- Level: Mid level
- Location: Emeryville, California, United States
- Work setup: On-site
- Posted: 2026-09-15
- Apply by: 2026-10-30
- Apply: https://job-boards.greenhouse.io/profluent/jobs/5425382008
- Page: https://www.1752.vc/careers/jobs/profluent-scientist-ii-delivery-for-large-gene-insertion/

## About the role

We are seeking a highly motivated, analytical, and innovative Scientist II to join our Platform Discovery team. In this role, you will lead efforts to solve fundamental challenges in non-viral delivery of DNA templates for recombinase-based large gene insertion. Your work will be foundational for expanding our broader gene editing toolbox and enabling new therapeutic opportunities.

## What they're looking for

- Lead the development, evaluation, and benchmarking of innovative non-viral methods for nucleic acid donor template delivery for recombinase-based large gene insertion
- Design and execute hypothesis-driven experiments to identify and overcome barriers to donor template stability, intracellular trafficking, and nuclear availability
- Develop quantitative assays to evaluate donor template delivery and connect these measurements to targeted insertion efficiency and fidelity
- Analyze data to drive critical go/no-go decisions, clearly present conclusions and rationale to stakeholders across the organization
- Collaborate with downstream translational teams to validate recombinase donor template delivery approaches in therapeutically relevant cell-based and in vivo systems
- Stay up to date on the latest developments in gene editing technology, delivery systems, relevant clinical applications, and cellular models

Tags: Biology