# Scientist II - Sr. Scientist, CRISPR Specificity & Genomic Safety at Profluent

- Company: Profluent
- What the company does: The next frontier is authoring new biology, and with AI, we have the power to write the future—creating solutions that transform medicine, agriculture, and beyond. Backed by Insight and Air Street.
- Company website: https://www.profluent.bio/
- Type: Startups (AI role)
- Level: Senior
- Location: Emeryville, California, United States; On-site
- Work setup: On-site
- Posted: 2026-06-02
- Apply by: 2026-10-08
- Apply: https://job-boards.greenhouse.io/profluent/jobs/5239820008
- Page: https://www.1752.vc/careers/jobs/profluent-scientist-ii-sr-scientist-crispr-specificity-and-genomic-safety/

## About the role

Profluent is seeking a creative and enthusiastic Scientist II - Sr. Scientist to build and apply experimental workflows that characterize the specificity, safety, and developability of our personalized CRISPR base editing platform. This role will initially focus on establishing and scaling base-editor specificity workflows , including biochemical and cell-based approaches such as CHANGE-seq-BE and related methods for identifying DNA and RNA off-target activity.

## What they're looking for

- Strong experimental background in molecular biology, mammalian cell culture, genome editing reagent delivery, NGS library preparation, assay troubleshooting, and quantitative analysis of editing outcomes
- Ability to design rigorous experiments with appropriate controls, replicates, sensitivity considerations, and clear decision criteria
- Experience with high-throughput or semi-automated workflows, process development, assay qualification, data tracking, and reproducible execution in a fast-paced research environment
- High level of attention to detail and commitment to generating high-quality, decision-enabling data
- Experience with cross-functional collaboration in a biotechnology setting, particularly with protein engineering, cell biology, computational biology, translational, or program teams
- Excellent communication skills and ability to present complex scientific concepts, datasets, limitations, and recommendations to colleagues and stakeholders

Tags: Biology