# Analytical Scientist I at Prolific Machines

- Company: Prolific Machines
- What the company does: Backed by SOSV.
- Company website: http://prolific-machines.com
- Type: Startups (AI role)
- Level: Mid level
- Location: Emeryville, California
- Work setup: On-site
- Pay: $120K to $140K base salary per year (USD)
- Posted: 2026-09-08
- Apply by: 2026-10-23
- Apply: https://jobs.lever.co/prolific-machines/6da02354-6980-471c-95da-f5cc10d5d79c
- Page: https://www.1752.vc/careers/jobs/prolific-machines-analytical-scientist-i/

## About the role

The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments.

## What they're looking for

- Have illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS)
- Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry
- Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics
- Have experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes
- Have hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software
- Are highly motivated to deliver successful outcomes for internal and external clients

Tags: Analytical Chemistry