# Senior Scientist, Analytical Operations at Prolific Machines

- Company: Prolific Machines
- What the company does: Difficult protein production made simple. A next-generation expression system for next-generation therapeutics. Backed by SOSV.
- Company website: http://prolific-machines.com
- Type: Startups (AI role)
- Level: Senior
- Location: Emeryville, California
- Work setup: On-site
- Pay: $150K to $180K base salary per year (USD)
- Posted: 2026-11-02
- Apply by: 2026-12-17
- Apply: https://jobs.lever.co/prolific-machines/9f6d0be2-003b-4700-bf01-05a4e2abfb41?utm_source=1752vc&utm_medium=careers
- Page: https://www.1752.vc/careers/jobs/prolific-machines-senior-scientist-analytical-operations/

## About the role

Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind optogenetic platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology enables dynamic, tunable control over virtually any cellular function in any cell type. Found on 1752vc Careers, the job board for startup and VC roles.

## What they're looking for

- Hold a PhD in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related field with 5+ years of biologics industry experience, or an MS/BS with equivalent relevant industry experience
- Have a track record of measurably improving the throughput, turnaround, or robustness of analytical workflows in a high-volume setting
- Have deep hands-on expertise in chromatographic and electrophoretic methods for biologics (e.g., Protein A, SEC, RP, IEX, CE-SDS, icIEF), including troubleshooting
- Have hands-on LC-MS experience for protein characterization (intact and subunit mass, peptide mapping, PTM and glycan analysis) and with MS data processing software
- Have led the characterization of a biologic for a project team: designing studies, interpreting complex or conflicting data, and making a clear recommendation
- Bring statistical thinking to experimental design and interpretation

Tags: Analytical Chemistry

Source: 1752vc Careers, https://www.1752.vc/careers/jobs/prolific-machines-senior-scientist-analytical-operations/