# Principal Scientist, ADME/PK at Shasqi

- Company: Shasqi
- What the company does: Shasqi uses click chemistry to target cancer drugs directly to the tumor, minimizing side effects and potentially improving the therapeutic index. Backed by Y Combinator.
- Company website: https://www.shasqi.com
- Type: Startups
- Level: Principal and up
- Location: United States
- Work setup: Remote
- Pay: $150K to $180K base salary per year (USD)
- Posted: 2026-05-21
- Apply by: 2026-10-08
- Apply: https://jobs.ashbyhq.com/shasqi/3b949921-3bd4-40cc-8ae6-c1f6f72bd0ba
- Page: https://www.1752.vc/careers/jobs/shasqi-principal-scientist-adme-pk/

## About the role

We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting. You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment.

## What they're looking for

- PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field
- 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs
- Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics)
- Strong experience designing and interpreting in vivo PK and biodistribution studies
- Demonstrated experience with QSP and PK/PD modeling
- Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar)

Tags: Research