# Senior Machine Learning Engineer at Tahoe Therapeutics

- Company: Tahoe Therapeutics
- What the company does: Reasoning models can now generate hypotheses in seconds. Verifying them requires biological ground truth. Tahoe is building that ground truth. Backed by General Catalyst and Amplify.
- Company website: https://www.tahoebio.ai/
- Type: Startups (AI role)
- Level: Senior
- Location: South San Francisco
- Work setup: On-site
- Posted: 2025-12-02
- Apply by: 2026-10-08
- Apply: https://jobs.lever.co/tahoebio-ai/7af0bf4e-54b9-420f-96fa-24058a2794af
- Page: https://www.1752.vc/careers/jobs/tahoe-therapeutics-senior-machine-learning-engineer/

## About the role

With Tahoe-100M, we solved one of the fundamental bottlenecks in building a virtual model of the cell: generating massive, perturbation-rich, single-cell datasets that capture real biological causality. With Tahoe-x1 , we removed the second bottleneck: creating a modern platform for rapid iteration on model architectures and designs in a cost-efficient manner and at scale.

## What they're looking for

- Solid Engineering and Computer Science fundamentals, ideally with a degree in CS, Math, or equivalent experience
- Exceptional engineering skills to iterate quickly on data processing and training pipelines
- Experience in building, testing, training, and deploying modern neural network architectures such as Transformers
- Experience with frameworks like PyTorch, Tensorflow, Keras, JAX and the ability to write hardware optimized code for distributed training
- Experience with distributed deep learning using frameworks such as HF Accelerate, Deepspeed, Composer, TorchTitan, Megatron etc
- Experience with training large neural networks on multiple compute nodes

Tags: Machine Learning