# Principal Scientist, Biology at Xaira

- Company: Xaira
- What the company does: We’re pioneering the discovery and development of life-changing medicines through the transformative power of artificial intelligence. Backed by Lightspeed, NEA and Sequoia.
- Company website: https://xaira.com/
- Type: Startups
- Level: Principal and up
- Location: South San Francisco, California, United States
- Work setup: On-site
- Pay: $164K to $205K base salary per year (USD)
- Posted: 2026-09-08
- Apply by: 2026-10-23
- Apply: https://job-boards.greenhouse.io/xairatherapeutics/jobs/5232474007
- Page: https://www.1752.vc/careers/jobs/xaira-principal-scientist-biology/

## About the role

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.

## What they're looking for

- PhD in Immunology or a related field with 6+ years of relevant experience
- Track record of impact through first-author publications, posters, and presentations at meetings
- Demonstrated ability to independently define research strategy, plan and oversee complex experiments, and interpret data to guide program direction
- Experience generating and advancing novel target hypotheses, with the scientific judgment to prioritize among competing ideas
- Strong expertise in in vitro and ex vivo immunology, including primary immune assays, co-culture systems, target cell depletion assays, and high-parameter flow cytometry
- Single-cell RNA sequencing (scRNAseq), CRISPR/Cas9, and omics data analysis experience is a plus

Tags: Biology & Pharmacology