Denali Therapeutics brings the power of biotherapeutics to the whole body, including the brain. We discover, develop and deliver medicines for people living with serious diseases. Backed by GV.
About the role
Lead and manage a group within the Nonclinical Safety Assessment and DMPK organization, providing strategic, project-focused vision and oversight to advance drug candidates from Discovery through CTA/IND-enabling studies into early clinical development ultimately supporting BLA submission. Deliver on Project Team objectives by contributing scientific expertise in pharmacokinetics, drug disposition, biodistribution, and translational pharmacology/pharmacodynamics.
What they're looking for
- Typically requires a PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology/Toxicology, Engineering, or a related field
- Typically requires 10+ years of relevant experience, including 8+ years of people management, mentorship, and coaching experience
- Established expertise in biotherapeutic drug disposition and pharmacokinetics, with a track record identifying clinical candidates and advancing molecules through CTA/IND milestones to first-in-human trials
- Proven ability to evaluate drug properties impacting PK, investigate PK/PD relationships, and apply relevant bioanalytical methods (ligand binding assays, mass spectrometry, or other methodologies)
- Demonstrated success leading and/or serving on cross-functional Project Teams, contributing to data-driven decision-making and drug development strategy
- This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future
More about this role
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This role leads a dedicated DMPK team within the Nonclinical Safety Assessment and DMPK group within the Development Sciences organization, providing scientific and strategic input to advance a portfolio of blood-brain-barrier penetrant biotherapeutics from Discovery through CTA/IND-enabling studies, as well as ultimately supporting registration. Serving as both a hands-on subject-matter expert and a people leader, this individual collaborates closely with Discovery Sciences, Translational Medicine, and Regulatory teams to shape PK, drug disposition, and translational pharmacology strategy across project teams. The incumbent builds scientific talent within the Nonclinical Safety Assessment and DMPK group and represents DMPK on the Development Sciences Leadership Team.
Lead and manage a group within the Nonclinical Safety Assessment and DMPK organization, providing strategic, project-focused vision and oversight to advance drug candidates from Discovery through CTA/IND-enabling studies into early clinical development ultimately supporting BLA...
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