Earli’s mission is to make cancer a benign experience by forcing it to reveal and kill itself. Backed by a16z and Menlo.
About the role
Earli Inc. is currently seeking a top caliber Senior Scientist, Bio AI to join our Synthetic Bioengineering team. If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.
What they're looking for
- You share our same sense of dedication, scientific passion and entrepreneurial spirit
- You work well in a fast-paced and extremely focused startup environment
- You are not only smart, but clever and constantly think outside the box
- You are able to make logical decisions in an instant when there is little time to evaluate
- You are a natural communicator and relationship builder
- You stay calm under high pressure and stress
More about this role
Earli tackles the #1 problem in the $100B cancer drug market: systemic toxicity. On-target/off-tumor effects force suboptimal dosing, reduced efficacy and sidelining some of the most potent drug classes such as cytokines. Earli’s BioAI approach flips this paradigm: Drugs are produced only where needed— in the tumor, by the tumor, against the tumor. Cancer cells become their own drug factories, enabling localized immune activation, even in cold tumors.
- Extrahepatic lipid nanoparticles (LNPs) that reach tumors such as lung cancer
- AI-designed genetic switches that activate only in malignant cells by sensing transcription factor dysregulation
- Local production of immune therapies (TCEs, cytokines, multispecifics) at the tumor site — “produce locally, consume locally”
Together, these technologies create a new biological control layer, allowing tumors to self-identify and trigger their own targeted immune attack—achieving specificity beyond current targeted or IO therapies.
Earli plans to enter the clinic by mid-2027 with a Phase 1/2 lung cancer trial. The company is backed by a16z, Khosla, Perceptive, Alex Gorsky, Marc Benioff, Breyer, Emerson Collective, Sands Capital and others....
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