ESM3. Enabling scientists to understand, imagine, and create proteins. Backed by Lux.
About the role
We are seeking an exceptional Postdoctoral Fellow/ Scientist I focusing on cell engineering with a creative mindset to drive innovative engineering and investigation of programmable immune cells with single-cell spatial precision. The successful candidate will integrate synthetic biology, spatial multi-omics, and systems-level analysis to engineer programmable cellular functions, investigate their activities in situ, and identify the molecular drivers of specific functional states.
What they're looking for
- Computationally design programmable molecular components (e.g., receptors and transcription factors)
- Engineer immune cells with these components and profile their behavior in tissue using spatial multi-omics (e.g., seqFISH+) to uncover cellular functions and engineering principles
- Analyze high-dimensional imaging and sequencing datasets using computational approaches to identify organizational and regulatory principles
- Collaborate closely with researchers across genomics, immunology, machine learning, and related disciplines
- Contribute to preprints, publications, presentations, and open science practices
More about this role
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Chan Zuckerberg Biohub New York (CZ Biohub NY, https://biohub.org/immune-cell-reprogramming/ ) is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and...
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