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About the role
Come join Alltrna and be an integral part of the Next-Generation Sequencing (NGS) Core within our Computational and Molecular Biology team. We are seeking a highly motivated and organized Research Associate to support the RNA-based NGS methods and experiments that empower Alltrna’s platform. The role will own end-to-end execution of NGS experiments, spanning sample extraction through sequencing, quality control, and documentation.
What they're looking for
- BS/MS in biology, molecular biology, biochemistry, or a related discipline, with 2+ years (RA II) or 4+ years (Senior RA) of relevant experience
- Hands-on experience with nucleic acids, including RNA/DNA extraction and quantification, PCR, qPCR, gel electrophoresis, and Illumina NGS library preparation
- Working understanding of the molecular biology and QC metrics that underlie NGS workflows and Illumina sequencing
- Ability to stay organized and complete a high volume of requests on time, while maintaining accuracy and quality
- Demonstrated ability to think critically, troubleshoot, and problem-solve
- Track record of identifying and contributing to data-driven workflow improvements
More about this role
Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.
Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics.
For more information, visit www.alltrna.com
Come join Alltrna and be an integral part of the Next-Generation Sequencing (NGS) Core within our Computational and Molecular Biology team. We are seeking a highly motivated and organized Research Associate to support the RNA-based NGS methods and...
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