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About the role
We are seeking a highly motivated Senior Scientist II with deep expertise in lipid chemistry to drive the design of novel ionizable lipids and the next generation of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on the rational design and synthesis of new ionizable lipids, the design of optimized LNP molar compositions, and the preparation of LNP formulations to screen and benchmark those new lipids. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- PhD. in Organic Chemistry, Medicinal Chemistry, Chemical Biology, Pharmaceutical Sciences or a related field, with 5+ years of relevant industry experience, or M.S. with 8+ years of experience
- Strong background in multi-step organic synthesis, purification and structural characterization, ideally of lipids, amphiphiles or other delivery materials
- Hands-on experience with LNP formulation (e.g., microfluidic mixing, nanoprecipitation) and an understanding of how lipid structure and molar composition drive potency, stability and tolerability
- Experience designing and running formulation screens, including characterization by DLS, encapsulation assays and pKa determination
- Experience with nucleic acid delivery (mRNA, DNA, siRNA) is highly preferred
- Familiarity with lipid analytics (NMR, LC-MS, HPLC-CAD/ELSD) and with computational or data-driven approaches to lipid design is a plus
More about this role
Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.
Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.
We are seeking a highly motivated Senior Scientist II with deep expertise in lipid chemistry to drive the design of novel ionizable lipids and the next generation of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on the rational design and synthesis of new ionizable lipids, the design of optimized LNP molar compositions, and the preparation of LNP formulations to screen and benchmark those new...
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