Pioneering Partnerships Latest News.
About the role
We are seeking a motivated and highly collaborative Senior Scientist to join FL129’s growing team of experimental and computational scientists to build a novel platform technology. The successful candidate will have a strong track record of scientific and technical innovation in DNA-encoded library (DEL) design, synthesis, and affinity-based selection.
What they're looking for
- Ph.D. in organic chemistry, medicinal chemistry, chemical biology, or a similar field with 5+ years of industry or postdoctoral experience
- End-to-end experience with DNA-encoded library (DEL) screening, from library design and synthesis through affinity selection, next-generation sequencing, and hit deconvolution
- Hands-on expertise in DNA-compatible chemistry, including split-and-pool combinatorial synthesis, building-block validation, and development or adaptation of reactions to on-DNA conditions
- Experience with encoding and tagging strategies, including barcode design and enzymatic ligation, and with analytical quality control of library synthesis (e.g., LC-MS)
- Experience with affinity selection formats and their controls, including immobilized and solution-phase targets, matrix and negative selections, and DNA-encoded positive controls
- Experience with on-DNA and off-DNA hit validation, including resynthesis and biochemical/biophysical assays to confirm and quantitate the bioactivity of screening hits
More about this role
What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?
Flagship Labs 129 (FL129) is an early-stage biotechnology startup with an ambitious and exciting mission: to unlock the future of small molecule drug discovery. FL129 is developing a revolutionary approach to this challenge and is recruiting a team of top-tier scientists to build this powerful and first-in-category platform. This is a unique opportunity to be one of the first employees of a biotech startup that combines an innovative mindset with the resources and know-how of Flagship Pioneering. This is a hands-on role with substantial ownership for a scientist who is excited to set technical direction from day one and, over time, help build the team.
We are seeking a motivated and highly collaborative Senior Scientist to join FL129’s growing team of experimental and computational scientists to build a novel platform technology. The successful candidate will have a strong track record of scientific and technical innovation in DNA-encoded library (DEL) design, synthesis, and affinity-based...
Browse similar: Venture capital jobs · VC platform and IR jobs