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(Senior) Scientist, Translational Biology

Flagship Pioneering · Cambridge, MA USA · On-site

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About Flagship Pioneering

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About the role

We are seeking a highly motivated and experienced Scientist to join our research team. The ideal candidate will have deep expertise in flow cytometry, primary cell isolation and sorting, microscopy and imaging, and gene-silencing techniques (siRNA), with in vivo/in vitro mouse experience. This role will contribute to the design and execution of preclinical studies to advance therapeutic programs. Found on 1752vc Careers, the job board for startup and VC roles.

What they're looking for

  • Ph.D. in Molecular Biology, Cell Biology, or a related field with 3–6+ years of relevant experience (industry preferred), or M.S. with significant experience
  • Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis (e.g., FlowJo or similar tools)
  • Hands-on experience with microscopy techniques (e.g., immunofluorescence, confocal microscopy) and associated image analysis software (e.g., ImageJ/Fiji, Imaris, or similar)
  • Demonstrated experience with siRNA design, delivery, and functional validation
  • Strong data analysis and problem-solving skills
  • Excellent communication and presentation skills
More about this role

FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering, which provides the strategic vision and resources to advance FL106 from platform validation to clinical impact.

We are seeking a highly motivated and experienced Scientist to join our research team. The ideal candidate will have deep expertise in flow cytometry, primary cell isolation and sorting, microscopy and imaging, and gene-silencing techniques (siRNA), with in vivo/in vitro mouse experience. This role will contribute to the design and execution of preclinical studies to advance therapeutic programs.

  • Design, execute, and analyze complex in vitro / in vivo experiments to support research programs
  • Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation
  • Perform and optimize primary cell isolation from tissues, including enzymatic and mechanical tissue dissociation, magnetic-activated cell sorting (MACS), and fluorescence-activated cell sorting (FACS), with attention to preserving cell viability, yield, native gene-expression signatures, and potential for...

Read the full posting on Flagship Pioneering's site ↗

Research/Discovery

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