Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
About the role
Design and execute rigorous experiments independently, troubleshoot issues, analyze complex data using advanced computational tools and software, and document results Drive screening efforts across multiple projects, leveraging a comprehensive toolkit of functional assays and technologies
What they're looking for
- Bachelor's degree and/or Master's degree in Cell Biology, Pharmacology, Biochemistry, or related field
- 8+ years of hands-on research experience in fast-paced pharma or biotech environments
- Expert-level proficiency in culturing and performing assays on a wide range of mammalian and primary cells (including cardiomyocytes), as well as in stable cell line generation and gene-editing techniques (e.g., CRISPR)
- Knowledgeable in G-protein coupled receptor (GPCR) signaling pathways, ligand-receptor binding kinetics, and standard pharmacological characterization
- Hands-on experience with a variety of microplate-format biochemical and cellular assays (e.g., HTRF, AlphaScreen, or luminescence-based readouts)
- A critical thinker with strong problem-solving abilities and scientific rigor
More about this role
Join Genentech's Biochemical and Cellular Pharmacology Department and help shape the future of cardio-metabolic therapeutics. We are seeking a creative, motivated scientist to drive the discovery and characterization of innovative drug candidates that could transform patient outcomes.
Operating at the intersection of cutting-edge science and drug development, you will support the selection and characterization of therapeutic candidates across our pipeline. In this role, you will develop, validate, and execute sophisticated biochemical and cell-based assays in heterologous and physiologically relevant systems to evaluate drugs in cardiovascular, renal and metabolic areas. You will support projects from initial lead finding through optimization, conducting detailed mechanistic studies on complex receptor signaling pathways and protein interactions. Ultimately, your scientific insights will help define target candidate profiles and shape the screening cascades that deliver our next-generation therapeutics.
Design and execute rigorous experiments independently, troubleshoot issues, analyze complex data using advanced computational tools and software, and document results
Drive...
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