Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
About the role
Provide Strategic Leadership: Serve as the primary GPCR expert and strategic advocate for Biochemical and Cellular Pharmacology on multidisciplinary project teams, contributing both at the bench and at leadership levels to drive decision-making. Drive Pharmacological Characterization: Oversee and contribute to rigorous in vitro pharmacological characterization to advance lead candidates in the cardiovascular, renal, or metabolic disease fields.
What they're looking for
- Ph.D. in Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline with 1–5 years of postdoctoral and/or industry experience
- Demonstrated expertise in receptor theory, signal transduction pathways, allosteric modulation, and biased signaling, along with hands-on experience across diverse GPCR assay platforms (e.g., cAMP, calcium flux, BRET/FRET, Beta-arrestin recruitment)
- Expertise in cardiovascular, renal, or metabolic disease fields
- Passionate about dissecting complex receptor pharmacology and translating its functional impact into disease-relevant biological readouts using advanced model systems
- Experience working with a wide range of primary cells and gene-editing techniques (e.g., CRISPR)
- Proven track record in developing, optimizing, and troubleshooting biochemical and cell-based assay cascades in primary and recombinant systems
More about this role
We are seeking a talented and highly motivated Senior Scientist to join our Biochemical and Cellular Pharmacology Department. The successful candidate will be part of a dynamic, highly collaborative team driving the discovery and characterization of innovative therapeutic drug candidates that could transform patient outcomes.
Operating at the intersection of cutting-edge science and drug development, you will play a crucial role in selecting and evaluating different modalities of therapeutic candidates from early-stage research to final IND candidate selection. In this role, you will apply your deep expertise in G-protein coupled receptor (GPCR) pharmacology to establish screening assay cascades and dissect complex receptor mechanisms of action to inform target candidate profiles. You will lead and contribute to the development, optimization, and execution of sophisticated molecular pharmacology assays, acting as a primary subject matter expert on project teams and shaping program directions.
Provide Strategic Leadership: Serve as the primary GPCR expert and strategic advocate for Biochemical and Cellular Pharmacology on multidisciplinary project teams, contributing both at the...
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